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复制驱动的HBVcccDNA损失在具有人性化的肝脏的仿真小鼠中.

Bai-Hua Zhang1, Yuanping Zhou2, Stephen Horrigan3

  • 1Virology, HBVtech, Rockville, Maryland, USA.

Journal of virology
|November 6, 2025
PubMed
概括

乙型肝炎病毒 (HBV) 感染的持续性依赖于共闭圆形DNA (cccDNA). 这项研究表明,感染HBV的细胞可以自发清除ccccDNA,停止病毒复制并防止无直接向的细胞病变效应.

关键词:
肝炎病毒复制的复制cccDNA的清除和补充.细胞病变影响 细胞病变影响持续的HBV感染.

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