遗传风险和体力活动与发生慢性阻塞性肺部疾病的关联:一项大型前性队列研究
Jin Yang1, Xiao Lin Wang1, Wen Fang Zhong1
1Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Biomedical and environmental sciences : BES
|November 6, 2025
概括
定期体力活动显著降低了慢性阻塞性肺病的风险,即使是具有高遗传倾向的个体. 定制活动干预对于那些基因易患COPD的人来说至关重要.
科学领域:
- 肺部医学 肺部医学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 构成了全球重大健康负担.
- 遗传倾向和生活方式因素,如体力活动,已知有助于COPD风险.
- 了解遗传风险和体力活动之间的相互作用对于有效的COPD预防策略至关重要.
研究的目的:
- 研究身体活动和遗传风险对慢性阻塞性肺病发展的独立和联合影响.
- 为了确定身体活动是否可以减轻不同遗传易感性的个体中COPD的风险.
主要方法:
- 对318,085名英国生物库参与者的前性队列研究.
- 使用国际体育活动问卷 (简短形式) 评估的体育活动.
- 根据多基因风险得分,参与者分为低基因风险,中基因风险和高基因风险组.
- 采用多变量考克斯回归和相互作用分析.
主要成果:
- 在13年的时间里,9209名参与者患上了COPD.
- 中等到高的体力活动与所有遗传风险层 (HRs从0.809到0.853不等) 的COPD危险比率降低有关.
- 观察到遗传风险和体力活动之间存在显著的相互作用,这表明了组合效应.
结论:
- 无论遗传风险如何,中度或高水平的体力活动都与较低的COPD风险有关.
- 这些发现强调了促进身体活动对预防COPD的重要性.
- 干预措施应考虑遗传易感性,以优化风险人群的有效性.
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