通过与不同多环芳香碳化合物代谢物相关的新型预防评估心血管疾病风险的不同亚型
Ye Xin1, Yu Cheng Sun1, Lin Chen1
1Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China.
Biomedical and environmental sciences : BES
|November 6, 2025
概括
多环芳 (PAH) 代谢物,如纳夫他林和,与心血管疾病 (CVD) 风险增加有关,特别是在年轻人中. 氨酸会影响老年人,而氨酸在老年人中显示出对心血管疾病亚型的保护作用.
科学领域:
- 环境健康 环境健康
- 心血管医学 心血管医学
- 毒理学 毒理学 毒理学
背景情况:
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 暴露于常见的环境污染物多环芳 (PAHs) 的人群健康问题越来越严重.
- 了解PAH代谢物对各种心血管疾病亚型的具体影响,对于风险评估和预防策略至关重要.
研究的目的:
- 研究各种多环芳 (PAH) 代谢物与不同心血管疾病 (CVD) 亚型风险之间的关联.
- 确定有助于心血管疾病风险的特定PAH代谢物,并探索这些关联中的与年龄相关的差异.
主要方法:
- 使用EVENTS PREVENT方程估计各种亚型的10年心血管疾病风险.
- 采用多重逻辑回归,加权量子量和 (WQS) 和量子量g计算 (qgcomp) 模型进行关联分析.
- 在不同年龄小组进行了分层分析,以检查效果的修改.
主要成果:
- 在PAHs,特别是 (NAP) 和 (FLU) 与总心血管疾病,动脉样性心血管疾病 (ASCVD) 和心力衰竭 (HF) 的风险之间发现了显著的积极关联.
- NAP和FLU被确定为PAH混合物效应的主要贡献者,在年轻的参与者 (30-49岁) 中有显著的关联.
- 氨酸 (PHEN) 在老年参与者 (≥50岁) 中显示出与ASCVD,HF,冠心病 (CHD) 和中风的主要关联,而氨酸 (PYR) 与这些心血管疾病亚型显示出负面关联,特别是在老年人中.
结论:
- 不同的PAH代谢物对特定的心血管疾病亚型产生不同的影响,显著的年龄相关影响.
- 纳夫他林和是导致心血管疾病风险的关键因素,特别是在年轻人群中.
- 皮雷恩对主要心血管疾病亚型具有保护作用,特别是在老年人中,突出显示了PAH暴露,心血管疾病和年龄之间的复杂相互作用.
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