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Updated: Jan 6, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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在癌症驱动基因中系统检测替代开放式读取 (altORFs)

Angelo Pavesi1

  • 1Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze, 23/A, 43124, Parma, Italy. angelo.pavesi@unipr.it.

Journal of molecular evolution
|November 6, 2025
PubMed
概括

研究人员在人类癌症基因中发现了251个新的替代开放阅读框架 (altORF). 一些altORF在哺乳动物中保存,可能代表治疗开发的癌症抗原的新来源.

关键词:
这是COSMIC数据库.进化性保护是一种进化性保护.基因表达 基因表达 基因表达突变的癌症基因发生突变叠加阅读框架的阅读框架预测算法 预测算法

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