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Updated: Aug 9, 2026

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可切除dMMR/MSI-H癌症的生物学和不断变化的管理:当前状况和未来前景

Tokiyoshi Tanegashima1, Masaki Shiota2, Kayo Toyosaki3

  • 1Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

Cancer immunology, immunotherapy : CII
|November 6, 2025
PubMed
概括

免疫检查点抑制剂对不匹配修复缺陷 (dMMR) 或微卫星不稳定性高 (MSI-H) 瘤有希望,可使器官保存. 需要进一步的研究来优化患者选择,并了解长期的结果.

关键词:
免疫检查点抑制剂 免疫检查点抑制剂在MSI-H中,您可以使用MSI-H.新辅助免疫疗法新辅助免疫疗法非操作性的非操作性.器官的保存 器官的保存dMMR 是一个MMR.

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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.