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萨科佩尼性肥胖与认知功能障碍和痴呆症的关联:系统审查和元分析
Chunbian Tang1,2, Ying Song3,4,5, Fengran Tao6
1Medical School of Tianjin University, Tianjin, China.
Aging clinical and experimental research
|November 6, 2025
概括
标本性肥胖 (SO) 与较高的认知功能障碍风险有关,其概率增加了71%. 然而,这些证据的确定性非常低,需要谨慎的解释和进一步的研究.
科学领域:
- 老年学和认知神经科学
- 代谢和肌肉骨健康
背景情况:
- 麻性肥胖症 (SO) 和认知衰退之间的关系尚未得到充分证实.
- 了解这种关联对于公共卫生至关重要,特别是在老龄化人口中.
研究的目的:
- 系统地审查和元分析关于sarcopenic肥胖和认知功能障碍或痴呆症之间的关联的观察性研究.
- 量化SO患者认知障碍的风险.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane Library,Web of Science,ClinicalTrials.gov) 进行了全面的文献搜索,截至2024年12月.
- 包括17项涉及274,996名参与者的观察性研究,11项使用随机效应模型进行定量元分析.
主要成果:
- 肥胖症与认知功能障碍的几率显著增加有关 (OR = 1.71,95% CI: 1.39-2.11).
- 在各种子组中观察到一致的关联,包括不同的研究设计,种群和定义萨科佩尼亚和认知功能障碍的方法.
- 亚组分析显示了男性,一般人群的显著关联,当肉症是由肌肉质量/功能或肌肉功能单独定义时.
结论:
- 肥胖症似乎与认知功能障碍有关.
- 高异质性,潜在的偏见和证据确定性非常低,需要谨慎地解释这些发现.
- 需要高质量的前性研究来证实这种关联并阐明潜在的机制.
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