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使用最小生理学基础的药理动力学建模,将贝瓦西祖马布的药理动力学从成年患者到儿科患者之间的桥梁

Olagoke Sule1,2,3, Felix Stader4, Nastya Kassir1

  • 1Genentech, Inc, 1 DNA Way, South San Francisco, California, 94080, USA.

The AAPS journal
|November 6, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模成功预测了儿科癌症患者的贝瓦西祖马布暴露. 这种方法有助于将药物数据从成年人推断到儿童,改善儿科瘤学药物开发.

关键词:
瘤学 在瘤学方面.儿科 儿科 儿科 儿科药学指标 药学指标 药学指标 药学指标基于生理学的药理动力学.

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