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接受不同折射校正的初级先天性玻璃眼儿童的视觉结果:CLEVR-PCG随机临床试验

Jinyun Jiang¹, Yin Hu¹, Yingting Zhu¹

¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

JAMA ophthalmology

|November 6, 2025

概括

刚性气体透性隐形眼镜 (RGPCL) 与眼镜相比,在初级先天性玻璃眼 (PCG) 手术后的儿童中显著改善了视力敏度和对比度灵敏度. 推使用RGPCL进行PCG康复,特别是那些眼镜反应不佳的人.

科学领域:

眼科医生眼科眼科
儿科眼科护理儿科眼科护理
玻璃眼研究研究玻璃眼研究

背景情况:

初级先天性玻璃眼 (PCG) 手术通常会导致儿童的残留视力损伤.
有效的视觉康复策略对于改善这些患者的治疗结果至关重要.

研究的目的:

为了比较刚性气透性隐形眼镜 (RGPCL) 与在PCG手术后儿童视力康复中继续佩戴眼镜的疗效.

主要方法:

一项随机临床试验,涉及56名儿童 (年龄为4-15岁),手术管理PCG和眼镜反应差.
参与者被随机分配到12个月内佩戴RGPCL (n=29) 或眼镜 (n=27),并进行标准化眼盲补丁.
主要结局是12个月后最差眼的最佳校正视敏度 (BCVA) 的变化;次要结局包括对比度敏感性和接近立体视敏度.

主要成果:

与眼镜组相比,RGPCL组的BCVA显著改善 (0.31对0.12 logMAR,P=.03).与眼镜组相比,RGPCL组的BCVA显著改善.
在RGPCL组中,更多的参与者实现了2线BCVA改善 (62.5%对37.5%,P=.01).
RGPCL还导致对比度灵敏度和近立体急性 (P=.04和P=.001分别) 的更大改善,没有严重的不良事件.

结论:

与PCG手术后儿童眼镜相比,刚性气体透性隐形眼镜提供了优越的视觉敏度和对比度灵敏度的好处.
RGPCL是PCG儿童视力康复的推选择,特别是那些眼镜反应不佳或视力度较差的儿童.

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