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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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mRNA m<sup>6</sup>A modifications and the RNA-binding protein YTHDF1 affect translational control in both normal and pathological learning.

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Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
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放射治疗在树突细胞中诱导YTHDF2,损害交叉呈现和T细胞功能.

Dapeng Chen1,2, Liangliang Wang3, Chuangyu Wen1,2

  • 1Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.

The Journal of experimental medicine
|November 6, 2025
PubMed
概括

放射治疗失败和转移与树突细胞 (DCs) 中辐射诱导的免疫抑制有关. 针对DC中的YTHDF2克服了这一问题,增强了癌症治疗和疫苗.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 分子生物学分子生物学

背景情况:

  • 转移性进展是放射治疗失败的主要原因.
  • 连接放射治疗与免疫抑制和转移的机制尚不清楚.

研究的目的:

  • 在树突细胞 (DC) 中识别辐射诱导的免疫检查点.
  • 研究YTHDF2在放射治疗耐药性和转移中的作用.
  • 探索YTHDF2向作为一种治疗策略.

主要方法:

  • 来自临床试验的患者活检的分析 (NCT03223155).
  • 研究了通过电离辐射对YTHDF2调节的分子机制.
  • 在临床前模型中评估YTHDF2对T细胞激活和瘤控制的影响.

主要成果:

  • 在放射治疗后的DC中增加YTHDF2表达与治疗失败相关.
  • 电离辐射会诱导SPI1,而SPI1则会在DC上调节YTHDF2.
  • YTHDF2促进了诺奇通路调节者的降解,损害了T细胞的激活,促进了免疫逃避.
  • 向YTHDF2恢复了DC免疫性,并增强了放射治疗的疗效.

结论:

  • 在DC中,YTHDF2充当辐射诱导的免疫检查点.
  • 准YTHDF2是一种有前途的策略,可以克服放射治疗耐药性和转移.
  • 结合YTHDF2抑制和放射治疗的联合治疗可以改善癌症治疗结果和基于DC的疫苗.