作为心脏手术预后生物标志物的N-终端前脑尿酸:系统性审查
Barbara Giovanna Souza Silva Queiroz1, Andressa Maranhão de Arruda1, Lara Maria Moura de Sá Villa-Chan2
1Universidade de Pernambuco Programa de Pós-Graduação em Ciências da Saúde Faculdade de Ciências Médicas Recife Pernambuco Brasil Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Pernambuco, Brasil.
Brazilian journal of cardiovascular surgery
|November 6, 2025
概括
在心脏手术前,N-终端脑前性尿素 (NT-proBNP) 水平升高可以预测患者的治疗结果不佳. 这种生物标志物表明诸如死亡率,长时间住院和手术后心力衰竭等风险.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 外科手术的结果
背景情况:
- N-终端亲大脑尿性 (NT-proBNP) 是一个关键的生物标志物,表明心脏应激和心力衰竭.
- 随着心脏纤维的拉伸,其产量增加,信号心肌张力.
研究的目的:
- 调查高NT-proBNP水平对接受心脏手术的患者不良结果的独立预测值.
- 确定NT-proBNP作为该患者群体的预后标志物.
主要方法:
- 对多个数据库 (PubMed,LILACS,PEDro,Web of Science,Embase) 进行了全面的系统审查.
- 搜索词集中在NT-proBNP和心血管外科手术程序上,不包括儿科,癌症和动物研究.
- 通过GRADE和PEDro等级来评估研究质量,并遵循PRISMA和PICO指南.
主要成果:
- 该审查包括47篇文章,其中17篇专门分析严重并发症,包括死亡率.
- 研究结果表明,NT-proBNP水平与不良事件之间存在相关性.
结论:
- 术前NT-proBNP水平作为各种术后并发症的显著预后标志物.
- 这些包括死亡率,延长ICU和住院时间,急性损伤,心房动,低心力输出,长时间通风,再入院和心力衰竭.
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