在先天性CMV中听力损失的临床特征和进展的风险因素
Lara Fusani1, Nadine Couzens2, Benedetta Bianchi3
1Department of Health Sciences, University of Florence, Florence, Italy.
International journal of audiology
|November 6, 2025
概括
在患有先天性细胞大脑病毒 (cCMV) 的婴儿中,晚期发作的感觉神经听力损失 (SNHL) 在未经治疗的儿童中更为常见. 持续的听力学评估至关重要,直到6岁由于晚期恶化模式.
科学领域:
- 儿科 儿科 儿科
- 听力学 听力学是指听力学.
- 传染性疾病 传染性疾病
背景情况:
- kongenital cytomegalovirus (cCMV) 是婴儿感觉神经听力损失 (SNHL) 的重要原因之一.
- 在cCMV中SNHL的风险因素和进展模式尚未完全理解.
- 需要进一步调查SNHL的特定模式,包括晚发性SNHL (LO-SNHL).
研究的目的:
- 描述cCMV的婴儿队列中SNHL的模式.
- 调查临床特征与SNHL的分布,时间和进展之间的相关性.
- 为了确定cCMV中SNHL恶化的风险因素.
主要方法:
- 匿名听力学,临床和治疗数据的回顾性审查.
- 包括来自两个医疗机构的61名患有cCMV和SNHL的儿童.
- 听力学评估,脑部成像和治疗持续时间的分析.
主要成果:
- 77%的儿童患有先天性SNHL,23%的儿童在平均年龄为4.7岁时发展出LO-SNHL.
- 在未接受治疗的儿童中,LO-SNHL发生的频率明显高于接受治疗的儿童.
- 所有测试的频率都受到影响;异常的大脑成像是常见的,正常的成像与较少的恶化相关.
结论:
- 在cCMV中,特别是在未经治疗的婴儿中,LO-SNHL是一个重大问题.
- 听力衰退的中位数年龄 (4.7岁) 凸显出需要长期的听力监测,长达5-6岁.
- 早期和持续的听力学监测对于在cCMV患者中管理SNHL至关重要.
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