患有心室辅助器械的儿童的传染性并发症:单中心回顾性队列研究
Raphael Seiler1, Nehle Speckmann1, Camilo Jose Hernandez Toro2,3
1Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease - Pediatric Cardiology, Augustenburger Platz, Berlin, Germany.
PloS one
|November 6, 2025
概括
表面感染 (SI) 在儿科心室辅助器件 (VAD) 治疗中很常见,但不会增加血液感染或死亡率. 三岁以上的儿童在VAD支持期间面临更高的SI发展风险.
科学领域:
- 儿科心脏病学 儿科心脏病学
- 医疗器械感染 医疗器械感染
- 机械循环支持 机械循环支持
背景情况:
- 对于患有末期心力衰竭的儿童,心室辅助器械 (VAD) 治疗至关重要.
- 感染带来重大风险,影响VAD患者的发病率和死亡率.
- 在VAD治疗期间,表面皮肤通/管感染 (SI) 是一个主要问题.
研究的目的:
- 在儿科VAD患者中识别表面感染 (SI) 的危险因素.
- 评估SI对VAD治疗总体结果的影响.
- 分析SI与其他并发症 (如血液感染和死亡率) 之间的关系.
主要方法:
- 70名儿科VAD患者感染并发症的回顾性分析.
- 使用了考克斯的比例危险模型和竞争风险模型.
- 研究的风险因素包括年龄,支持续时间,基础诊断和之前的胸切除术.
主要成果:
- 表面感染 (SI) 发生在17%的儿童中,每100个患者月发生事件率为5.86.
- 年龄较大 (3岁以上) 是SI的重要风险因素 (HR 2.67).
- SI与增加血液感染风险 (HR 1.27) 或死亡率 (HR 0.32) 无关.
结论:
- 表面感染在儿科VAD治疗中很常见,但不会增加血液中感染或死亡率.
- 在VAD植入时超过三岁的儿童患SI的风险更高.
- 较长的支时间与SI发生相关,而诊断和之前的手术没有.
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