或不用于低风险差异化甲状腺癌:我们应该如何将研究结果应用于英国实践中? 一个专家的共识意见
K Newbold1, N Armstrong2, M Beasley3
1The Royal Marsden NHS Foundation Trust, London, UK.
概括
或不 (IoN) 试验显示,省略放射性切除对于差异化甲状腺癌无复发存活率是不劣的. 这支持节省患者不必要的治疗和相关的不良事件.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 临床试验 临床试验
背景情况:
- 差异化甲状腺癌 (DTC) 管理通常包括放射性除除.
- 或不 (IoN) 试验调查了这种消去在低风险DTC的必要性.
- 改变实践的证据需要更新的临床指南.
研究的目的:
- 建立英国关于实施IoN试验结果的全国共识.
- 根据新的证据,指导早期,低风险的DTC管理.
- 为临床医生提供有关调整治疗方案的信息.
主要方法:
- 召集一个由英国甲状腺癌专家组成的多学科小组.
- 进行虚拟会议以分析 IoN 试验数据.
- 为临床实践制定基于共识的立场陈述.
主要成果:
- 该ION试验证明了遗漏放射性切除的无复发生存率的非劣势性.
- 这提供了1级证据,用于降低低风险DTC的治疗升级.
- 制定了一份带有建议的立场声明.
结论:
- 该ION试验提供了强有力的证据,以避免在精选的DTC患者中进行放射性切除.
- 这种方法可以减少与治疗相关的不良事件.
- 拟议的立场声明有助于将这些发现纳入英国临床实践,以便在改变指南之前.
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