2型糖尿病患者体质指数,骨矿物质密度和骨骨分数之间的相关性
1Department of Radiology, Jinjiang Municipal Hospital, Shanghai Sixth People's Hospital Fujian, 362200, Jinjiang, Fujian, China.
概括
在2型糖尿病中,较高的体重指数 (BMI) 与较高的骨矿物质密度 (BMD) 相关,但骨微型架构较差. 这种效应在绝经后的女性中显著,突出显示了椎骨分数 (TBS) 作为早期指标.
科学领域:
- 内分泌学和新陈代谢学
- 骨生物学和骨质疏松症的研究
- 糖尿病研究研究 糖尿病研究
背景情况:
- 2型糖尿病 (T2DM) 与改变的骨代谢有关.
- 在T2DM中,体质指数 (BMI),骨矿物质密度 (BMD) 和骨微型结构之间的相互作用需要进一步阐明.
- 脊椎骨评分 (TBS) 提供了超越BMD的骨微型架构的见解.
研究的目的:
- 调查BMI和区域性BMD以及TBS在T2DM成年人之间的关系.
- 为了确定年龄或性别是否改变了这些关系.
- 评估TBS在T2DM患者的临床实用性与正常的BMD.
主要方法:
- 追溯分析了762名成年人 (≥50岁),包括257名T2DM患者和505名对照患者.
- 腰椎和大腿部部BMD和TBS的双能X射线吸收度数据.
- 使用斯皮尔曼 ρ 和多重线性回归的统计评估,根据年龄和性别进行调整.
主要成果:
- 在男性中,在T2DM和对照组之间没有观察到BMI,BMD或TBS的显著差异.
- 与对照组相比,50-60岁的T2DM女性的腰椎骨质量较高,但TBS较低.
- 多变量分析显示,BMI是LS-BMD的独立正预测因子,是T2DM中TBS的负预测因子.
结论:
- 在T2DM中较高的BMI独立地与增加的BMD相关,但损害了椎骨微型架构.
- 骨和微型架构之间的这种分离在绝经后的女性中尤为明显.
- 在T2DM中,当BMD在正常范围内时,TBS可以作为评估T2DM骨健康的有价值的早期预警工具.
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