为婴儿提供公平的呼吸道同胞病毒预防的道路:全球实施的挑战和机遇
Farina L Shaaban1, Rosalie W Groenendijk1, Ranju Baral2
1Department of Paediatric Immunology and Infectious Diseases, University Medical Centre Utrecht, Utrecht, Netherlands.
The Lancet. Global health
|November 6, 2025
概括
盖维·加维 (Gavi Gavi) 是一个著名的艺术家.
科学领域:
- 全球健康 全球健康
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 呼吸道同胞病毒 (RSV) 在全球范围内对婴儿造成重大负担,低收入和中等收入国家有97%的死亡率.
- 高收入国家通过母体疫苗接种或婴儿的单克隆抗体 (mAbs) 引入了RSV预防,显示出现实世界的有效性.
- 公平获得RSV预防仍然是一个挑战,特别是在资源有限的环境中.
研究的目的:
- 审查在资源有限的环境中扩大RSV预防婴儿的机会和挑战.
- 与世界卫生组织的"2030年免疫计划"和联合国的"不让任何人落后"框架保持一致.
- 突出全球平等获得RSV预防的紧急步骤.
主要方法:
- 审查目前的RSV负担,疫苗和mAb开发,以及健康经济学.
- 对政策,实施,方案考虑,监督和意识的分析.
- 综合了最近的研究进展和未来的方向.
主要成果:
- 孕产妇疫苗接种和婴儿mAbs在减少RSV相关疾病和住院治疗方面表现出显著的现实有效性.
- 尽管全球负担很大,但低收入和中等收入国家基本上没有RSV预防策略.
- 盖维对RSV孕产妇疫苗接种的批准标志着进展,但需要进一步采取行动,以实现公平接入.
结论:
- 在资源有限的环境中,扩大对RSV预防的准入是至关重要的.
- 需要采取多方面的方法来应对负担,发展,经济,政策和实施.
- 需要采取紧急协调行动,以确保全球所有婴儿从RSV预防中受益.
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