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Alicia Madurga¹, María Sanz-Felisi¹, Ariadna Arbiol-Roca¹

¹Clinical Laboratory, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.

Clinica chimica acta; international journal of clinical chemistry

|November 6, 2025

概括

本研究通过使用refineR算法为孕妇建立了第一季度甲状腺刺激激素 (TSH) 参考间隔 (RIs). 这些新的RI改善了在怀孕早期的TSH水平的解释.

科学领域:

临床化学临床化学
内分泌学在内分泌学.
生殖医学生殖医学

背景情况:

在怀孕期间,甲状腺刺激激素 (TSH) 的解释需要三个月特定的参考间隔 (RIs).
人口变化需要更新RI以进行准确的TSH评估.
确定第一季度的TSH RIs对于在怀孕早期管理甲状腺功能至关重要.

研究的目的:

在孕妇中建立第一季度TSH参考间隔 (RIs).
为了使用间接的refineR算法来准确地确定RI.
提供更新的TSH RIs,以改善怀孕早期的临床解释.

主要方法:

一项回顾性观察性研究分析了来自第一季度孕妇的4185个TSH结果.
使用refineR算法和Python进行数据管理和统计分析.
使用独立数据集和前性研究来验证参考间隔.

主要成果:

第一个三个月的TSH参考间隔 (RIs) 确定为0.46 (CI 0.37-0.55) 到4.91 (CI 4.09-5.62) mIU/L.
这项研究包括一个大型队列,包括4185名孕妇,主要是白种人.
通过二次数据集和前性队列验证了所获得的RI.

结论:

本研究介绍了使用refineR方法获得的怀孕第一季度的第一个TSH参考间隔.
已建立的RI提供了一个有价值的工具,用于准确的TSH解释在怀孕早期.
这些发现支持使用refineR来生成可靠的三个月特定的TSH参考间隔.

关键词:

怀孕的第一季度怀孕的第一季度现实世界的数据数据.参考时间间隔的参考时间间隔甲状腺刺激激素激素刺激的激素改进Ralgorithm的算法

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