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TERT激活剂化合物通过调节海马体炎症和神经发生来缓解香烟烟雾引起的认知缺陷:整合孟德尔随机化的综合性研究

Zhiying Zheng¹, Chaochao Chen¹, Shouqiang Zhu¹

¹Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China; Medical School, Nanjing University, Nanjing 210093, China.

Experimental neurology

|November 6, 2025

概括

吸烟对认知功能和阿尔茨海默病的风险有因果影响. 用一种新型化合物激活端粒酶逆转录酶 (TERT) 在小鼠中逆转了这些有害影响,表明TERT是治疗点.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
药理学药理学是指药理学的学科.

背景情况:

吸烟是一个公共卫生问题,对认知的影响有争议.
遗传研究表明,吸烟行为与阿尔茨海默病风险增加之间存在联系.

研究的目的:

使用孟德尔随机化 (MR) 和体内模型研究吸烟与认知功能之间的因果关系.
评估基于端粒酶的干预措施,以治疗吸烟引起的认知障碍.

主要方法:

两个样本的孟德尔随机化 (MR) 分析.
在体内小鼠模型使用香烟烟雾提取物 (CSE).
行为测试 (恐惧调节,Y-迷宫),分子测试 (IBA1,细胞因子,BDNF,DCX),RNA测序,以及RT-qPCR/TERT.的西方涂抹.
用TERT激活剂化合物 (TAC) 进行药理干预.

主要成果:

在东亚和欧洲人口中,MR证实吸烟行为增加了阿尔茨海默病的风险.
在小鼠中,CSE暴露导致认知缺陷,海马炎症,减少BDNF和成人海马神经发生障碍 (AHN).
CSE抑制了海马体端粒酶逆转录酶 (TERT) 的表达.
在暴露于CSE的小鼠中,TAC治疗恢复了TERT,减少了神经炎症,增加了BDNF和AHN,并改善了认知能力.

结论:

暴露在香烟烟雾中会通过神经炎症和减少神经生成损害认知功能.
药理上激活TERT可提供神经保护,防止吸烟相关的认知缺陷.
TERT是吸烟相关的认知障碍的潜在治疗标.

关键词:

香烟烟雾的烟雾是什么意思认知缺陷是一个认知缺陷.门德尔的随机化分析.神经新生是神经发生的过程.这就是为什么 TERTTT.

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