在高和低性能水平的健康老年人中,肠道微生物群的组成和长期体力活动
Giovanni Fiorilli1, Alessandro Medoro1, Elisa Viciani2
1Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, 86100, Campobasso, Italy.
Experimental gerontology
|November 6, 2025
概括
定期的体力活动,无论是高强度还是低强度,都能促进老年人肠道微生物多样性和有益细菌. 这与久坐式衰老形成鲜明对比,强调运动.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 运动科学 运动科学
背景情况:
- 衰老与肠道微生物多样性减少有关,这种过程可能因久坐的生活方式而恶化.
- 长期以不同强度的体力活动对老年人肠道微生物群的影响尚不清楚.
研究的目的:
- 研究高性能 (HP) 和低性能 (LP) 身体活动对老年人肠道微生物群组成的长期影响.
- 为了比较身体活跃的老年人与年龄相匹配的身体不活跃的对照人群的肠道微生物特征.
主要方法:
- 在48个月后,从老年成人 (71-84岁) 的便样本中对肠道微生物群概况的截面分析.
- 参与者的分层分为HP,LP和身体不活跃的对照组.
- 微生物群的概况,以评估多样性和社区结构.
主要成果:
- 与不活跃的对照组相比,身体活跃的老年人表现出明显更高的肠道微生物多样性和独特的社区结构.
- 无论是HP和LP组,都显示出对短链脂肪酸 (SCFA) 生产细菌的丰富,包括特定物种,如Phocaeicola vulgatus和Bacteroides uniformis.
- 惠普组特别显示了Turicibacter sanguinis和Eubacterium oxidoreducens的丰富,与血清素信号传递和SCFA生产有关.
结论:
- 长期的体力活动,无论表现水平如何,都会对老年人肠道微生物群的组成产生积极的影响.
- 定期炼可能有助于减轻与年龄相关的肠道微生物多样性和功能的下降.
- 与SCFA生产和神经递质信号传递相关的特定细菌种群在老龄化人口中受到物理活动的调节.
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