在疫情爆发期间,使用培养和分子方法从病房废水中检测Candidozyma (前Candida) auris
H C Davidson1, A-E Griffin1, L Symes1
1School of Health and Medical Sciences, City St George's University of London, London, UK.
The Journal of hospital infection
|November 6, 2025
概括
在疫情爆发期间,废水监测有效地检测到医院病房中的Candida auris. 这种方法提供了一种敏感的,成本效益高的替代方案,用于早期检测患者查.
科学领域:
- 传染性疾病 传染性疾病
- 环境微生物学 环境微生物学
- 公共卫生监督 公共卫生监督
背景情况:
- 黄是一种多药耐药的真菌,导致昂贵的医院爆发.
- 传统的C. auris患者查是资源密集的,可能不具有成本效益.
- 废水监测提供了一个潜在的病房级早期检测策略.
研究的目的:
- 评估在医院病房废水中检测C. auris的可靠性.
- 将基于培养和PCR的废水方法与患者殖民查进行比较.
- 在活跃的C. auris疫情期间评估废水监测.
主要方法:
- 在疫情爆发期间,从12个医院病房收集的废水和环境样本.
- 直接培养,丰富和AurisID®实时PCR试验被用于检测.
- 全基因组测序分析了患者和废水分离物之间的遗传关系.
主要成果:
- 培养方法显示75%的灵敏度和100%的特异性.
- 在AurisID® PCR中显示出100%的灵敏度和75%的特异性.
- 全基因组测序证实了废水和患者C. auris分离物之间的克隆性.
结论:
- 在医院病房的废水中检测到C. auris的第一份报告,使用培养和PCR.
- 污水查可能是个体患者查的敏感,具有成本效益的替代方案.
- 为了实施废水监测,建议进行进一步的纵向研究.
关键词:
它们是Candida auris.坎迪多西马奥里斯 (Candidozyma auris) 是一个疫情爆发的原因是监督 监督 监督 监督 监督 监督病房的废水是病房的废水.废水是废水,废水就是废水.更多相关视频
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