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Updated: Jan 12, 2026

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通过单细胞和单样本基因调控网络探索急性髓性白血病患者的异质性

Leandro Fernandes1, Edoardo Saccenti1

  • 1Laboratory of Systems and Synthetic Biology, Wageningen University & Research, The Netherlands.

Biochimica et biophysica acta. Gene regulatory mechanisms
|November 6, 2025
PubMed
概括

单细胞基因调节网络揭示了急性髓性白血病 (AML) 患者的独特特征. 这种方法准确地区分了AML患者,为个性化生物标志物和治疗铺平了道路.

关键词:
树状细胞 树状细胞机器学习 机器学习单细胞细胞的单细胞细胞.预测建模的预测建模.原始细胞是原始细胞.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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