儿科眼部表面炎症疾病:临床特征和实践模式
Simon S M Fung1, Tanya Boghosian2, Claudia Perez3
1Department of Ophthalmology, University of California San Francisco, San Francisco, CA.
Cornea
|November 6, 2025
概括
儿童眼部表面炎症疾病 (POSID) 管理显示过度依赖皮质类固醇和免疫调节剂的使用不足. 这导致了像眼这样的渐进性并发症,凸显了改善治疗策略的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 儿科医学 儿科医学
- 现实世界的证据 现实世界的证据
背景情况:
- 儿童眼部表面炎症性疾病 (POSID) 包括诸如白色眼结膜炎 (BKC),简单疹结膜炎 (HSK) 和春季结膜炎 (VKC) 等疾病.
- 了解现实世界的实践模式和并发症对于优化儿童护理至关重要.
研究的目的:
- 描述全国范围的现实世界实践模式和儿科眼表面炎症疾病 (POSID) 的并发症.
- 为了确定患有POSID的儿童眼的危险因素.
主要方法:
- 使用美国医疗保险索赔数据库 (2018-2019) 诊断出POSID的18岁以下患者的回顾性队列研究.
- 对从6个月前到3年后的临床数据进行分析.索引访问.
- 多变量逻辑回归用于确定眼风险因素.
主要成果:
- 与BKC和VKC相比,HSK的角膜痕 (7.5%) 和病 (5.5%) 的发病率较高.
- 高强度局部皮质类固醇经常被处方,而局部免疫调节剂被使用不足 (1.7%).
- 眼的患病率在3年内增加到4.5%,其中肌肉痕和高强度皮质类固醇使用是独立的风险因素.
结论:
- POSID亚型具有明显的临床特征和管理差异,随着时间的推移会出现渐进的并发症.
- 目前全国的做法显示过度依赖皮质类固醇和免疫调节剂的使用不足,与指导方针不同.
- 早期识别,类固醇节约疗法和持续的炎症控制是必要的,以便在儿科眼表表面炎症疾病中获得更好的结果.
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