抗血管内皮生长因子治疗的有效性和血管再发育,用于第2阶段早期诊断的家族排泄性维特雷雷诺病症
Haonan Ma1,2, Jie Peng1, Jianing Ren1,2
1Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Retina (Philadelphia, Pa.)
|November 6, 2025
概括
抗血管内皮生长因子 (VEGF) 疗法有效治疗婴儿的第2阶段家族排泄性玻璃色素变异症 (FEVR),促进视网膜持续的血管生长. 这种治疗有望改善早期诊断FEVR的结果.
科学领域:
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
- 儿科医学 儿科医学
背景情况:
- 亲属排泄性玻璃内膜病变 (FEVR) 是一种影响视网膜血管化的遗传性疾病.
- 早期诊断和干预对于管理FEVR以预防视力丧失至关重要.
- 第二阶段FEVR在血管发育方面提出了特定的挑战.
研究的目的:
- 评估抗血管内皮生长因子 (VEGF) 治疗2期FEVR在3个月前诊断的婴儿的疗效.
- 调查抗VEGF治疗对FEVR持续外周血管生长的影响.
- 为了确定影响治疗后血管生长的因素.
主要方法:
- 对14名被诊断患有2期FEVR的3个月以下的14名患者的24只眼睛进行了回顾性研究.
- 通过对抗VEGF治疗的反应来评估治疗结果.
- 使用盘血管化边缘/盘 (DB/DF) 比率评估血管生长.
主要成果:
- 抗VEGF治疗导致79%的眼睛回归,其中13%显示持久性,8%进展.
- 视网膜血管在治疗后继续呈现逐步增长 (β = 0.0010,P < 0.001).
- 相对的DB/DF比率显著增加,直到治疗后35.4周.
结论:
- 抗VEGF疗法在早期诊断的2期FEVR时有效地回归高血管活动.
- 治疗似乎促进了受影响眼睛中持续的外周血管生长.
- 这种方法为管理FEVR和维护视觉功能提供了一个潜在的策略.
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