低血清25-基维生素D作为社区老年男性虚弱的危险因素:一项韩国全国性的研究
Jeongmin Lee1, Min-Gu Kang2,3, Jeonghoon Ha4
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Endocrinology and metabolism (Seoul, Korea)
|November 6, 2025
概括
低维生素D水平与老年男性的虚弱风险增加有关. 这项研究在脆弱的男性中发现血清25-氧维生素D (25[OH]D) 度较低,这表明潜在的危险因素.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D在生物过程中起着至关重要的作用,但其与与生物衰老相关的脆弱性相关的关系尚未完全理解.
- 脆弱性对老年人的健康和独立性产生重大影响,强调需要确定可修改的风险因素.
研究的目的:
- 为了研究血清25-基维生素D (25[OH]D) 水平与韩国老年人的脆弱状态之间的关系.
- 利用一个全面的脆弱指数 (FI) 和一个具有全国代表性的数据集来探索这种关联.
主要方法:
- 这是一项涉及65岁及以上6589名参与者的横截面研究,来自韩国国家健康和营养检查调查 (2008-2012).
- 使用基于38个身体,认知,心理和社会项目的赤字积累脆弱指数 (FI) 来评估脆弱性.
主要成果:
- 与非脆弱男性相比,脆弱男性的血清25度显著降低 (降低6.8%).
- 在最低的25~OH) D四分位数中,男性的FI高5.3%,脆弱的几率增加了1.71倍. 维生素D缺乏 (<30nmol/L) 与男性的FI增加9.6%有关.
- 在女性中,血清25(OH) D和脆弱性之间没有显著的关联.
结论:
- 低血清25 ((OH) D度被认为是脆弱的潜在危险因素,特别是在老年男性中.
- 建议进行进一步的研究,以探索维生素D补充剂在缓解高危老年人脆弱性的有效性.
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