左心房硬度指数在SLE患者的诊断影响与左心室透静功能障碍
Xiaofang Zhong1, Yingying Pan1, Lixiong Liu2
1Department of Ultrasound, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.
Lupus science & medicine
|November 6, 2025
概括
左心房硬度指数 (LASI) 能够有效地检测左心室扩张性功能障碍 (LVDD) 在患有系统性红斑狼 (SLE) 的患者中. 与其他标志物相比,LASI显示出更高的诊断准确性,有助于在SLE患者中早期发现LVDD.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 系统性红斑狼 (SLE) 可能会影响心脏功能,特别是腹功能.
- 左心室扩张功能障碍 (LVDD) 是SLE患者常见的并发症.
- 早期评估LVDD对于管理SLE心血管风险至关重要.
研究的目的:
- 评估左心房硬度指数 (LASI) 对SLE患者LVDD的诊断影响.
- 为了比较LASI的诊断性能与传统的心声回声学参数和LA压力测量.
主要方法:
- 145名SLE患者和57名健康对照人接受了斑点跟踪心声扫描 (STE).
- 测量了传统的心声回声学参数和左心房 (LA) 菌株.
- 使用STE衍生的LA菌株和其他参数计算了LASI.
主要成果:
- 患有SLE的患者表现出增加的LA大小和减少的LA功能,具有更高的LASI,特别是患有狼性炎的患者.
- LASI与年龄,腹腔间隔膜厚度和E/e'正相关,与LA排空分数和LA菌株负相关.
- 与其他措施相比,LASI显示了LVDD的优异诊断性能 (AUC=0.919).
结论:
- LASI 准确地反映了 SLE 患者的 LA 功能变化.
- 与现有的心声学参数相比,LASI为LVDD提供了更高的诊断准确性.
- LASI 是一种有前途的潜在标志物,用于SLE早期LVDD检测.
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