降低动态大脑活动和功能连接在非功能性垂体腺瘤与视力障碍的功能连接
Jing Tang1, Wencheng Shen2, Pingyi Zhu3
1From the Department of Radiology (J.T., M.L., B.H., F.L., Y.W.), Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
AJNR. American journal of neuroradiology
|November 6, 2025
概括
视力受损的非功能性垂体腺瘤 (NFPA) 患者显示脑活动和视觉区域的连接性降低. 这些变化与瘤大小和视野缺陷相关,揭示了对NFPA神经病理学的新见解.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 非功能性垂体腺瘤 (NFPA) 可以通过缩压缩引起视觉障碍.
- 在视力受损患者中,已知存在大脑功能障碍,但动态大脑活动特征尚未得到充分探索.
研究的目的:
- 探索视力受损NFPA患者自发大脑活动和功能连接的时间变异性变化.
- 为了研究大脑动态变化与缩压缩严重程度和视野缺陷之间的关系.
主要方法:
- 休息状态功能性MRI (fMRI) 用于36名NFPA患者和36名对照人群.
- 低频波动的动态振幅 (dALFF) 和动态功能连接 (dFC) 分析评估了时间变化.
- 评估了与阴体积,压缩持续时间和视野缺陷严重程度的相关性.
主要成果:
- 与对照组相比,NFPA患者在舌环 (LING) 和骨裂 (CAL) 中显著减少了dALFF.
- 在患者的右侧LING和双边前之间观察到dFC的显著减少.
- 改变的dALFF与阴体积和平均偏差 (视野缺陷严重程度) 有积极的相关性.
结论:
- 视力受损的NFPA患者表现出大脑活动和视觉相关区域内连接的时间变异性下降.
- 这些发现为NFPA视觉障碍背后的神经病理机制提供了新的见解.
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