修改为曼诺斯的Prunus persica核蛋白纳米颗粒装载贝卡林,涂上Lycium barbarum多糖,用于治疗性结肠炎
Chunxiao Tao1, Fazhen Luo1, Yaxin Wang1
1Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Carbohydrate polymers
|November 6, 2025
概括
灰巴巴多糖 (LBP) 和普鲁努斯珀西卡核蛋白 (PKP) 形成了新型纳米粒子,用于向输送贝卡林 (Ba) 来治疗性结肠炎 (UC). 这种纳米药物通过改善结肠向和调节肠道微生物群来增强Ba的有效性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米医学是一种纳米医学.
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 治疗受限于抗炎药物如百卡林 (Ba) 的溶解性差和结肠向效率低下.
- 利巴巴鲁姆多糖 (LBP) 具有作为结肠向载体的潜力,因为其稳定性,生物相容性和调节肠道微生物群的能力.
研究的目的:
- 开发使用LBP,曼诺和Prunus persica核蛋白 (PKP) 的新型聚合物纳米粒子 (Ba@MP/LBP NPs),用于增强肠道向输送贝卡林治疗性结肠炎.
- 在性结肠炎模型中评估Ba@MP/LBPNP的物理化学性质,体内性能和治疗疗效.
主要方法:
- 聚合物纳米粒子 (Ba@MP/LBP NPs) 使用LBP,曼诺斯和PKP进行合成,封装了baicalin.
- 纳米粒子的特征包括形态,粒子大小,表面电荷和封装效率.
- 活体疗效在性结肠炎模型中进行了评估,重点关注结肠向,巨细胞吸收,肠道微生物群调节和抗炎作用.
主要成果:
- Ba@MP/LBP NPs表现出球形的核心外结构,粒子大小约为230 nm,表面负电荷 (-33.89 mV) 和高贝卡林封装效率 (94.26%).
- 这种LBP涂层促进了上部胃肠道的通行,并有针对性地传递到结肠,从而使炎症性巨细胞通过曼诺酶受体介导的内细胞形成.
- 用Ba@MP/LBPNP治疗有效地恢复了肠道微生物群平衡,抑制了促炎因素和氧化应激,缓解了UC症状,并证明了有利的生物安全性.
结论:
- 这项研究首次使用LBP和PKP作为在UC治疗中提供贝卡林的结肠向载体.
- 开发的Ba@MP/LBPNP显示出作为有效治疗性结肠炎的纳米药物的显著潜力,通过提高baicalin的治疗疗效和安全性.
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