白细胞ADAM10和ADAM17调节细菌和病毒性肺炎的疾病严重程度和系统性结局
Ahmad Aljohmani1, Christian Herr2, Martin Witzenrath3
1Molecular Pharmacology, PZMS, PSH, CGBM, ZHMB, Saarland University, Homburg, Germany.
白细胞蛋白酶ADAM10和ADAM17,在外体释放,显著影响肺炎的严重程度. 它们的失调有助于在病毒和细菌感染中引起炎症和疾病进展.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 肺炎是由SARS-CoV2和Pseudomonas aeruginosa等病原体引起的,由于蛋白酶失调可能会危及生命.
- ADAM10和ADAM17是关键的蛋白酶,涉及到炎症过程.
研究的目的:
- 系统地描述ADAM10和ADAM17在病毒性和细菌性肺炎中的白细胞和循环外体的贡献.
- 研究这些蛋白酶在疾病发病和进展中的作用.
主要方法:
- 对细菌性肺炎和COVID-19病例患者样本的分析.
- 使用缺乏白细胞ADAM10或ADAM17的条件淘汰小鼠进行体内研究.
- 细胞培养实验用于机械洞察力.
主要成果:
- 在患者中,外体ADAM10和ADAM17活性增加与肺炎严重程度相关.
- 具有高蛋白酶活性的外体诱导了心肌细胞和内皮壁垒的病理生理变化.
- 来自白细胞的ADAM10促进了促炎反应,而ADAM17似乎抑制了炎症.
结论:
- 白细胞ADAM10和ADAM17,通过外体,是肺炎的关键调节者.
- 外体细胞可能导致疾病进展和全身炎症.
- ADAM10和ADAM17需要进一步研究肺炎的诊断,预后和治疗潜力.
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