相关实验视频

Updated: Jan 12, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

在糖尿病足中识别和验证新的与炎症反应相关的诊断生物标志物

Sen Cai¹, Lingtao Xu¹, Shaole Wan¹

¹Hand surgery/wound reconstruction surgery, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.

Journal of diabetes investigation

|November 6, 2025

概括

这项研究确定了四个关键基因 (FOSL1,HBEGF,S100A12,TICAM1) 作为糖尿病足 (DFU) 的潜在诊断生物标志物. 这些基因与皮肤细胞分化和炎症有关,为DFU诊断提供了新的基础.

科学领域:

基因组学就是基因组学.
生物标志物发现发现
糖尿病并发症糖尿病并发症

背景情况:

糖尿病足 (DFU) 是一个重大的全球健康挑战.
慢性炎症是DFU的标志,但其诊断效用尚未完全理解.

研究的目的:

确定糖尿病足 (DFU) 病理学的关键基因和分子机制.
通过综合生物信息学分析发现DFU的潜在诊断生物标志物.

主要方法:

权重基因共同表达网络分析 (WGCNA) 和蛋白质-蛋白质相互作用 (PPI) 网络构造被用于从DFU样本数据中识别关键基因.
接收器操作特征 (ROC) 曲线分析评估了已识别的基因的诊断疗效.
进行了非负矩阵因子化,功能丰富分析和免疫透分析 (ssGSEA).

主要成果:

通过ROC分析确定并验证了具有DFU诊断潜力的四个特征基因 (FOSL1,HBEGF,S100A12,TICAM1).
这些基因主要参与质化和表皮细胞分化.
在这些基因的表达和免疫细胞透之间观察到负相关性.

结论:

这项研究确定了与炎症反应和皮肤细胞分化相关的DFU新型诊断基因.
这些发现为糖尿病足的早期诊断和有针对性的治疗提供了理论基础.

关键词:

糖尿病足部糖尿病足部诊断生物标志物的生物标志物.与炎症反应相关的基因

更多相关视频

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

A Simplified Technique for Producing an Ischemic Wound Model

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

相关概念视频

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...