向铁亡:在MAFLD中取得的新见解和治疗进展使T2DM复杂化
Fang Yao1,2, Gaochao Wang1,2, Fan Ning1,2
1Department of Endocrinology, Zhejiang Chinese Medical University Affiliated Jiaxing Traditional Chinese Medicine Hospital, 314000 Jiaxing, Zhejiang, China.
Frontiers in bioscience (Landmark edition)
|November 6, 2025
概括
作为细胞死亡过程的铁亡,越来越多地与2型糖尿病 (T2DM) 和代谢相关的脂肪肝疾病 (MAFLD) 相关. 向ferroptosis显示出治疗这些相互关联的疾病的希望.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 2型糖尿病 (T2DM) 和代谢相关脂肪肝疾病 (MAFLD) 的患病率正在同步上升.
- 同时发生会增加代谢障碍和疾病进展的风险,包括纤维化和恶性瘤.
- 炎症,胰岛素抵抗和细胞衰老等复杂的机制是这些疾病的基础.
研究的目的:
- 审查有关T2DM和MAFLD的铁亡研究的最新进展.
- 为突出潜在的治疗策略,针对ferroptosis临床应用.
主要方法:
- 对铁,T2DM和MAFLD研究的文献综述.
- 分析涉及铁过载,活性氧物种和脂质过氧化的机制.
- 检查影响铁亡的治疗剂和化合物.
主要成果:
- 铁,以铁的积累和脂质过氧化为特征,在T2DM和MAFLD的发展和进展中起着重要作用.
- 细胞内铁过载,高反应性氧物种和脂质过氧化是铁灭的关键因素.
- 抗糖尿病药物 (甲福明,皮奥格利塔,利拉格卢) 和向铁终结剂1 (FOT1) 显示出抑制铁亡和治疗T2DM相关的MAFLD的潜力.
结论:
- 铁亡是T2DM相关的MAFLD的一个关键机制.
- 向铁亡是一种有希望的治疗途径,用于管理这些相互关联的代谢疾病.
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