从长椅到运动:通过3D人体器官解开运动生物学
Limin Xu1,2,3, Yu Wang4,5, Chenshi Xi4
1National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875 Beijing, China.
Frontiers in bioscience (Landmark edition)
|November 6, 2025
概括
人类特有的有机体和先进的工程为研究运动生物学提供了新的途径. 这些模型有助于理解生理适应,并为与不活动相关的疾病开发个性化药物.
科学领域:
- 运动生物学 运动生物学
- 再生医学是一种再生医学.
- 系统生物学 系统生物学
背景情况:
- 运动适应的机制尚未完全理解.
- 动物模型由于物种间的差异而存在局限性.
- 诱导多能干细胞 (iPSC) 衍生器官使人类特异性研究成为可能.
研究的目的:
- 通过人类特异型模型,审查运动生物学研究中的转型策略.
- 突出器官和工程系统在研究运动适应性的潜力.
- 探索运动相关疾病的精准医学方面的进步.
主要方法:
- 利用运动员衍生的有机体来研究表观遗传记忆.
- 使用光遗传学和微流体学的工程系统来模拟生理条件.
- 应用多omics映射来识别运动响应路径.
主要成果:
- 运动员器官可以保存运动诱导的表观遗传记忆.
- 工程系统可以模拟机械力和系统信号.
- 多omics揭示了运动反应途径,如线粒体生物发生.
结论:
- 患者特异性器官模型桥梁病理生理学和高通量查.
- 这些模型推进了针对个性化训练和疾病治疗的精准医学.
- 机器人技术彻底改变了运动生物学研究.
相关概念视频
Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Skeletal Muscle Anatomy
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
The Functions of the Skeletal System
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Gross Anatomy of Skeletal Muscles
The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
Axial and Appendicular Muscles
Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and play a...
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and play a...


