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Updated: Jan 12, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Published on: April 4, 2025

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一种独特的抑制剂构造选择性地准了Gram阳性优先病原体的DNA聚合酶PolC

Mia Urem1,2, Annemieke H Friggen1, Nina Musch1

  • 1Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.

Nature communications
|November 6, 2025
PubMed
概括

针对PolC酶的新型抗微生物抑制剂提供了针对耐药性格拉姆阳性病原体的新策略. 结构洞察力揭示了这些抑制剂如何与DNA结合,阻止复制并为新的抗生素开发铺平道路.

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