基线肠道微生物群的组成会影响对现实世界食纤维干预的反应
Fabiana A Hoffmann Sardá1,2,3, Eliana B Giuntini1,3, Aline Oliveira1
1Department of Food Sciences and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
NPJ biofilms and microbiomes
|November 6, 2025
概括
富含粉的耐药未成熟香面粉 (UBF) 在富含Prevotella肠道微生物群的个体中显著改变了肠道微生物群和功能. 这凸显了基于现有的肠道微生物群组成的个性化食纤维干预的潜力.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 食纤维,特别是耐性粉 (RS),影响肠道微生物群.
- 未成熟的香面粉 (UBF) 是RS的丰富来源.
- 个体肠道微生物群的组成可以显著不同.
研究的目的:
- 研究富含RS的UBF和胰岛素对肠道微生物群和肠道功能的影响.
- 根据基线组成,确定UBF和胰岛素是否根据基线组成不同调节肠道微生物群.
- 评估这些纤维对胃肠道参数和宿主生物化学的影响.
主要方法:
- 一个双盲,随机,安慰剂控制的试验试验,涉及48名健康成年人.
- 干预组接受了马尔托德克斯 (对照),胰岛素或UBF六周.
- 分析包括16S rRNA基因测序,用于功能预测的PICRUSt,便短链脂肪酸和胃肠道参数.
主要成果:
- 确定了两个基线肠道微生物群群:富含普雷沃特拉菌 (P) 和富含细菌菌 (B).
- UBF的消费导致了显著的全球微生物群和功能转移 (533个KEGG正义词) 仅在集群P对象中.
- 胰岛素在P (19KOs) 中显示了适度的调节,但在B中没有影响.
结论:
- 富含RS的UBF以一种依赖于基线组成的方式调节肠道微生物群.
- 基于微生物群的分层可能会提高食纤维干预措施的有效性.
- 作为调节肠道微生物群的功能性食品成分,UBF显示出前景.
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