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腺三酸盐对大鼠氧化中毒性的保护作用

Ertugrul Erhan¹, Zeynep Suleyman², Durdu Altuner³

¹Department of Otorhinolaryngology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Türkiye.

Scientific reports

|November 6, 2025

概括

腺三酸盐 (ATP) 减轻了在老鼠中氧化 (HCQ) 诱导的耳毒性. ATP保护前庭耳神经组织免受氧化损伤,并减少HCQ引起的组织病理变化.

科学领域:

耳毒性研究研究
神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

已知氧化 (HCQ) 会引起耳毒性.
氧化应激在HCQ诱导的耳毒性中起作用.
腺三酸盐 (ATP) 具有潜在的保护性质.

研究的目的:

在大鼠模型中研究ATP对HCQ诱导的耳毒性产生保护作用.
为了评估ATP在HCQ给药后在前庭耳神经中对氧化应激标志物的影响.

主要方法:

24只雄性Wistar大鼠被分为四组:对照组,单独使用ATP,单独使用HCQ和ATP+HCQ.
鼠每天接受10天内内注射ATP (4mg/kg) 或盐水.
HCQ (120 mg/kg) 在ATP/盐水后1小时口服.
静脉耳神经组织分析了氧化剂/抗氧化剂参数和组织病理学变化.

主要成果:

ATP显著抑制了前庭耳神经组织中HCQ诱导的马隆迪甲 (MDA) 的增加.
ATP减弱了由HCQ引起的抗氧化剂水平 (谷氨,超氧化物脱酶,催化酶) 的下降.
组织病理学检查显示,ATP减少了HCQ治疗的老鼠的胀,血管拥堵和原沉积.

结论:

ATP显示出对氧化诱导的耳毒性有显著的保护作用.
ATP可以缓解前列耳神经的氧化损伤和相关的组织病理变化.
ATP可能是预防或减少HCQ相关听力损伤的潜在治疗剂.

关键词:

亚丁酸三酸盐是一种氨酸三酸盐.抗氧化剂是一种抗氧化剂.氧化chloroquine 的使用情况.氧化剂是一种氧化剂.在前庭耳道耳道.

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