通过开放科学环境加强转移性癌症的转化研究:UPTIDER经验
Anirudh Pabba1, Marion Maetens1, Amena Mahdami1
1Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
NPJ precision oncology
|November 6, 2025
概括
为死后组织捐赠计划建立开放科学环境 (OSE) 改善了对转移性癌症样本的获取. 这种方法通过提高数据和样本的可访问性以促进协作和发现来加速翻译性研究.
科学领域:
- 在瘤学瘤学.
- 翻译研究是翻译研究.
- 这是生物银行.
背景情况:
- 转移性癌症的翻译研究面临挑战,因为样本的可用性有限.
- 死后组织捐赠计划对于获得全面的转移样本至关重要.
- 维持这些计划需要一个开放的科学环境 (OSE) 进行协作和数据共享.
研究的目的:
- 为了证明在死后组织捐赠计划的上游阶段实施OSE的好处.
- 介绍机构死后组织捐赠计划UPTIDER (NCT04531696),作为OSE实施的模型.
- 突出OSE如何通过确保及时获取信息来加速翻译研究.
主要方法:
- 开发一个电子病例报告表格,捕捉超过750个临床特征,包括治疗线和转移.
- 实验室信息管理系统的实施追踪了100多个元数据特征.
- 整合代码版本系统,长期数据和样本存储以及数据/代码共享政策.
主要成果:
- 在UPTIDER程序成功地集成了一个OSE,包括全面的数据收集和管理.
- 该OSE促进多学科合作,规范研究实践,并确保患者的隐私.
- 建立的OSE可以及时获取关键信息,从而增强加速翻译研究的潜力.
结论:
- 为UPTIDER计划开发的机构OSE展示了一个可行的模型,用于增强死后组织捐赠倡议.
- 在生物银行流程中上游实施OSE是克服转移性癌症研究样本限制的关键.
- 来自UPTIDER的经验提供了一个可扩展的框架,可以激发和指导全球类似计划的开发.
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