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赫西丁和多草药口水对口腔微生物和用户满意度的影响:一项随机对照试验

Waris Wattanawongwan^1,2, Annop Krasaesin², Thutchima Khieota²

¹Dual-Degree Program in Oral Biology D.D.S.-M.Sc, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Clinical oral investigations

|November 6, 2025

概括

一种新的多草药口水是一种有前途的,患者接受的替代赫西丁 (CHX) 治疗牙炎的替代品. 它选择性地调节口腔微生物群,保持多样性,不像CHX,它可以引起失生症.

科学领域:

口腔微生物学口腔微生物学
微生物组研究的研究.
自然产品疗法自然产品疗法

背景情况:

牙炎的管理通常涉及消毒性口水,如赫西丁 (CHX).
CHX可以导致微生物失调,改变天然的口腔微生物群.
探索CHX的天然替代品对于最大限度地减少不良影响至关重要.

研究的目的:

为了比较多草药,CHX和普通盐水口水对口腔微生物群的影响.
评估患者报告的每个口水的结果.
评估多草药口水作为天然的,对微生物友好的CHX.替代品.

主要方法:

一个随机的双盲试验,涉及27名牙炎患者.
参与者使用多草药,CHX或正常盐水口水7天.
使用16S rRNA测序分析的唾液样本;通过数值评分尺度评估患者的结果.

主要成果:

多草药口水显示患者接受度 (味道,气味,质地,满意度) 比CHX和普通盐水显著更高.
CHX 破坏了微生物的多样性,增加了异位生物的种类 (例如,Streptococcus,Porphyromonas),改变了 23 种代谢途径.
多草药口水 (含CPC) 选择性地增加了有益的属 (例如,Amnipila),保留了多样性,并且只调节了两个路径.

结论:

多草药口水是一种可行的CHX替代品,提供选择性微生物调制和更好的患者接受.
它保持了口腔微生物组的稳定性,表明了日常口腔护理的潜力.
建议在不同人群中对无CPC配方进行进一步的研究.

关键词:

16S rRNA 测序的测序方法素替代品素替代品牙炎是一种炎症.牙炎相关的生理不良.口腔微生物组是口腔的微生物组.患者的满意度患者的满意度多草药口水是多草药的口水.普雷沃特拉 (Prevotella) 在投票中表示支持.

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