甲状腺功能低下,动脉样硬化和心血管风险预防
Leonidas H Duntas1, Ulla Feldt-Rasmussen2,3
1Evgenidion Hospital Unit of Endocrinology, Diabetes, and Metabolism, Thyroid Section, National and Kapodistrian University of Athens, Athens, Greece. leonidas@duntas.gr.
Nature reviews. Endocrinology
|November 6, 2025
概括
甲状腺功能低下,或甲状腺激素的产生减少,增加心血管疾病 (CVD) 的风险,特别是通过动脉样硬化. 本综述探讨了改善甲状腺功能低下患者心血管疾病预防和管理的机制和危险因素.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 甲状腺功能低下症影响约5%的人口,导致代谢和内分泌的变化.
- 它与心血管疾病 (CVD) 风险增加有关,主要是通过加速动脉样硬化.
- 与亚临床甲状腺功能低下症相关的心血管疾病风险需要进一步调查.
研究的目的:
- 审查甲状腺功能低下症和心血管风险因素之间的关系.
- 探索生物化学和分子机制,将甲状腺功能低下症与心血管疾病联系起来.
- 为了确定在甲状腺功能低下症中改善心血管疾病的管理和预防策略.
主要方法:
- 现有文献的叙述性审查.
- 检查传统和新型心血管风险因素.
- 分析甲状腺激素在心脏功能和结构中的作用.
主要成果:
- 甲状腺功能低下症与动脉样硬化加速和心血管疾病风险增加有关.
- 生物化学和分子途径有助于在甲状腺功能低下症中增加心血管疾病易感性.
- 甲状腺激素影响心脏结构和功能,影响心血管疾病的发展.
结论:
- 了解甲状腺功能低下症与心血管疾病的联系对于风险评估至关重要.
- 对于患有心血管疾病风险的甲状腺功能低下患者,需要个性化治疗方法.
- 对亚临床甲状腺功能低下症和心血管疾病的进一步研究是有必要的.
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