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可注射的氨酸水凝通过结构工程的化物功能化β-环极衍生物交叉连接,用于长期控制的伏利康纳输送

Chao Yang^1,2, Meng Xin³, Yufu Jiang¹

¹College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, Shandong, China.

AAPS PharmSciTech

|November 6, 2025

概括

可注射的氨酸水凝为眼部疾病提供长期控制的药物释放. 这些基于β-cyclodextrin的新型水凝显示出出色的生物相容性和持续的药物输送超过60天.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
眼科医生眼科眼科

背景情况:

从注射水凝中长期控制药物释放用于眼部疾病仍然是一个重大挑战.
现有的治疗方法往往需要频繁注射,这会影响患者的服从性和治疗结果.

研究的目的:

开发和描述新的可注射的氨酸 (HA) 基水凝,用于持续的眼部药物输送.
为了研究不同类型的化物功能化β-环极素 (β-CD) 衍生物对水凝特性和药物释放动力学的影响.

主要方法:

通过阿米诺功能化HA (NHA) 和三种基功能化β-CD衍生物 (ACD,ALCD,ABCD) 之间的希夫基反应合成可注射的基于HA的水凝.
使用FTIR,SEM和动态风力学对水凝成分,结构和性能进行表征.
开发的水凝的药物释放特征 (Voriconazole) 和细胞兼容性的评估.

主要成果:

合成的水凝表现出适合注射的微观结构和质性质,孔径为50-250微米,凝时间为60-300秒.
水凝实现了长期控制释放沃里康纳超过60天,在后期阶段具有近于零级的动力学.
观察到很好的细胞兼容性,特别是NHA/ACD和NHA/ABCD水凝配方.

结论:

用化-β-CD衍生物功能化的可注射HA基水凝显示出在治疗慢性眼病中长期控制药物输送的显著潜力.
这项研究为设计先进的注射药物输送系统提供了对β-CD衍生物的结构-性质关系的宝贵见解.
这些水凝为持续治疗提供了一个有前途的平台,可能会减少频繁眼球注射的需要.

关键词:

化物聚β-环氧二烯.药物输送是药物输送的过程.可以注射的水凝.这里是船只基地.沃里康纳 (Voriconazole) 是一种可以

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