在pMDIs中用于内部流量的新型端到端模拟框架:对化,闪沸和原子化的合建模
Mona Mohammadkhani1, Janusz Kozinski1, Leila Pakzad2
1Lakehead University, 955 Oliver Road, Thunder Bay, P7B 5E1, Canada.
AAPS PharmSciTech
|November 6, 2025
概括
一个新的多相模型模拟了压力计量剂量吸入器 (pMDIs),揭示了内部流动动态,如腔化和闪沸. 这种经过验证的框架准确地预测了气溶羽毛的特性,有助于为各种治疗用途优化pMDI.
科学领域:
- 流体动力学 流体动力学
- 气溶科学是一门气溶科学.
- 计算建模计算建模
背景情况:
- 压力计量剂量吸入器 (pMDIs) 广泛使用,但通常性能不佳.
- 现有的模型缺乏全面性,阻碍了从推进剂注入到羽毛形成的pMDI低效率的理解.
研究的目的:
- 开发和验证一个新的多相计算框架来模拟内部的pMDI流现象.
- 为了准确预测气溶羽毛的特征和动态.
主要方法:
- 使用流体体积 (VOF) 方法进行多相流体模拟.
- 捕捉到的关键现象:空洞化,快速沸和原子化.
- 使用高速成像和X射线成像数据验证了模型.
主要成果:
- 该模型准确地复制了实验羽毛的特征,包括质量中介直径 (2.7μm与3μm).
- 预测的初始喷射速度 (~110 m/s) 和角 (~21°) 与高速成像数据保持一致.
- 对多个实验数据集的预测能力证明.
结论:
- 开发的VOF框架为了解和优化pMDI性能提供了一个强大的工具.
- 允许针对各种治疗应用的吸入器设计进行配方特定的优化.
- 通过超越通用方法,推进定制的pMDIs的开发.
更多相关视频
09:39A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
Published on: May 9, 2016
8.3K
11:14A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
Published on: January 10, 2017
12.1K
相关概念视频
Typical Model Studies
610
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
610
Steady, Laminar Flow in Circular Tubes
1.0K
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is purely axial,...
1.0K
Laminar and Turbulent Flow
10.5K
Fluid dynamics is the study of fluids in motion. Velocity vectors are often used to illustrate fluid motion in applications like meteorology. For example, wind—the fluid motion of air in the atmosphere—can be represented by vectors indicating the speed and direction of the wind at any given point on a map. Another method for representing fluid motion is a streamline. A streamline represents the path of a small volume of fluid as it flows. When the flow pattern changes with time, the...
10.5K
Couette Flow
894
Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...
894
Accelerating Fluids
2.1K
When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
2.1K
Modeling and Similitude
598
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
598
