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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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RPL29作为多发性骨髓瘤中放射治疗敏感的预后生物标志物.

Yihua Wang1,2, Qi Jia3, Hongxiu Liu1

  • 1Second Hospital of Shanxi Medical University, Taiyuan, 030001, China.

World journal of surgical oncology
|November 6, 2025
PubMed
概括

放射治疗后的核糖体蛋白L29 (RPL29) 下调与多发性骨髓瘤 (MM) 的更好的结果相关. 这将RPL29确定为MM患者的潜在预后生物标志物.

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科学领域:

  • 血液瘤学 血液瘤学
  • 辐射瘤学 辐射瘤学
  • 分子生物学分子生物学

背景情况:

  • 多发性骨髓瘤 (MM) 是一种严重的血液性恶性瘤,放射治疗进展有限.
  • 放射治疗对MM的分子影响尚不清楚,尽管它有缓解作用.
  • 这项研究调查了RPL29作为MM中的新型放射治疗反应基因.

研究的目的:

  • 在多发性骨髓瘤中识别放射治疗敏感基因.
  • 评估RPL29在MM中的预后和治疗意义.
  • 探索MM中放射治疗的分子效应.

主要方法:

  • 使用了小鼠模型,放射治疗,RNA测序 (RNA-seq),qPCR和生物信息学.
  • 包括临床MM患者样本用于验证.
  • 进行了差异基因表达分析,并构建了蛋白质-蛋白质相互作用网络.

主要成果:

  • 在放射治疗后,RNA-seq发现了424个上调调节的基因和33个下调调节的基因.
  • 在对2Gy放射治疗的反应中,RPL29持续下调,与RPL19不同.
  • 在MM细胞系和患者样本中验证了RPL29下调.

结论:

  • 在 2 Gy 放射治疗后的 RPL29 下调与改善的MM 预后有关.
  • RPL29作为MM的潜在预后生物标志物.
  • 研究结果支持针对性治疗策略,涉及MM中的RPL29.