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通过PIM3抑制进行代谢重编程,可以逆转在固体瘤中缺氧诱导的CAR-T细胞功能障碍

Muya Zhou1, Luxia Xu2, Jinhua Hu2

  • 1Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China. muyazhou@njnu.edu.cn.

Journal of translational medicine
|November 6, 2025
PubMed
概括

缺氧会损害固体瘤中CAR-T细胞的功能. 抑制PIM3可以逆转这种功能障碍,增强抗瘤活性并改善治疗潜力.

关键词:
化学抗原受体 (CAR) -T细胞疗法氧气过低是因为缺氧.在PIM3中使用PIM3.固体瘤是一个固体瘤.瘤微环境是一个微环境.

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