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新生儿败血症基础过量的实用性:系统性审查和元分析

Ghea Mangkuliguna¹, Muhammad Ifan Romli², Nicholas Adrianto¹

¹School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.

Journal of neonatal-perinatal medicine

|November 7, 2025

概括

基础过量 (BE) 显示为诊断新生儿败血症的生物标志物具有前途,其降低的水平与较高的死亡风险有关. 由于临床使用前的证据确定性较低,因此需要进一步研究.

科学领域:

新生儿医学新生儿医学
生物标志物生物标志物
关键的护理关键的护理

背景情况:

败血症是新生儿死亡和疾病的主要原因.
新生儿败血症的早期诊断是困难的,因为模糊的症状和目前的诊断限制.
血气分析指标基础过量 (BE) 可能很快表明败血症的代谢变化.

研究的目的:

为了评估Base过量 (BE) 在识别新生儿败血症的诊断准确性.
评估BE在预测新生儿败血症死亡风险方面的预后价值.
根据PRISMA指南,通过元分析综合现有证据.

主要方法:

在多个数据库中进行了全面的文献搜索.
包括的研究测量了新生儿败血症病例中的BE.
两变随机效应模型被用于对灵敏度,特异性和AUC的元分析;死亡风险通过几率比率进行评估.

主要成果:

动脉/毛细血管血液中的BE值≤-5mEq/L显示了85.8%的灵敏度和82.9%的特异性 (AUC 0.909).
带血BE ≤-10mEq/L具有高特异性 (96.7%),但敏感性低 (10.3%).
较低的BE水平与死亡风险增加3.14倍相关;证据确定性低.

结论:

基础过量 (BE) 显示出作为新生儿败血症快速生物标志物的潜力.
目前的证据的确定性很低,需要进一步的前性研究来验证.
在临床采用之前,BE在联合诊断算法中的作用需要进一步探索.

关键词:

基数过剩的情况.这是一个元分析.新生儿败血症新生儿败血症系统性审查系统性审查

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