相关实验视频
Updated: Jan 12, 2026
10:28
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
10.2K
实体器官移植接受者肝炎E病毒查:患病率和实施影响,西班牙,2021年至2023年
Sara Pereira1, Alfredo Pérez-Rivilla2, Raquel Carracedo1
1Clinical Microbiology Unit, Hospital Clínico Universitario de Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.
概括
肝炎E病毒 (HEV) 感染在西班牙0.53%的实体器官移植接受者中存在,慢性感染率为0.32%. 在这个脆弱人群中,建议定期对HEV进行分子监测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 移植医学 移植医学 移植医学
背景情况:
- 肝炎E病毒 (HEV) 感染在固体器官移植 (SOT) 接受者中具有重大临床挑战,因为存在持续感染的风险.
- 欧洲指导方针主张在SOT接收者中进行HEV查,但常规实施仍然不够理想.
- 未被识别的HEV感染可能会导致免疫受损个体的严重并发症.
研究的目的:
- 确定西班牙SOT接收者中HEV病毒病的流行率.
- 评估这一队列中HEV感染的临床进展和病毒持续性.
- 在SOT接受者的HEV查和管理方面为临床实践提供信息.
主要方法:
- 在西班牙进行了一项多中心,横截面的研究,涉及940名成人SOT接受者.
- 患者在外周血液中被前性地测试了HEV RNA.
- 患有可检测的HEV病毒病的个体每三个月进行一次随访,以监测病毒的持续性.
主要成果:
- 该研究发现西班牙SOT接受者中HEV感染的患病率为0.53% (95%CI:0.23-1.24).
- 在所有成功基因定型的病例中,发现了E型肝炎3型基因.
- 在5名感染患者中,有3名患者表现出持续的HEV RNA阳性,这表明研究群体中慢性感染的流行率为0.32%.
结论:
- 这些发现强调了在SOT接受者中实施HEV定期分子监测的必要性.
- 积极的查和监测可以帮助检测和管理HEV感染,可能防止慢性疾病的进展.
- 这项研究强调了关于在SOT接受者中进行HEV查的推指南和临床实践之间的差距.
相关概念视频
01:28Kidney Transplant I: Introduction
315
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
315
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
171
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
171
01:26Diseases of the Liver and Gallbladder
1.8K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.8K