Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same author

Colloidal rod dynamics under large amplitude oscillatory extensional flow.

Soft matter·2026
Same author

Drying-Induced Packing and Coalescence of Monodisperse Oil Droplets in Aqueous Suspensions.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Revealing intrinsic electric double layer viscoelasticity in ionic liquid solutions <i>via</i> quartz crystal microbalance.

Soft matter·2025
Same author

Microrheological study on the entanglement dynamics of salt-free polyelectrolyte solutions in the semidilute entangled regime.

Polymer journal·2025
Same author

Active Microfluidic Platforms for Particle Separation and Integrated Sensing Applications.

ACS sensors·2025

相关实验视频

Updated: Jan 12, 2026

Nanomoulding of Functional Materials, a Versatile Complementary Pattern Replication Method to Nanoimprinting
10:49

Nanomoulding of Functional Materials, a Versatile Complementary Pattern Replication Method to Nanoimprinting

Published on: January 23, 2013

12.1K

分子印记纳米粒子 (NanoMIPs) 的固相工程:模板和固相如何驱动聚合物组成和结合性能.

Teresa Bosch-Tamayo1, Tamara M Iakimova1, Amy Q Shen1

  • 1Micro/Bio/Nanofluidics Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan. mark.sullivan@oist.jp.

Journal of materials chemistry. B
|November 7, 2025
PubMed
概括

固相合成显著影响分子印制聚合物纳米粒子 (nanoMIPs). 与磁纳米颗粒相比,玻璃珠支产生更高的结合亲和力,突出了合成受体的关键设计因素.

更多相关视频

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

30.0K
Author Spotlight: Exploring Self-Assembled MOF-Polymer Composites
06:48

Author Spotlight: Exploring Self-Assembled MOF-Polymer Composites

Published on: June 14, 2024

2.5K

相关实验视频

Last Updated: Jan 12, 2026

Nanomoulding of Functional Materials, a Versatile Complementary Pattern Replication Method to Nanoimprinting
10:49

Nanomoulding of Functional Materials, a Versatile Complementary Pattern Replication Method to Nanoimprinting

Published on: January 23, 2013

12.1K
Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

30.0K
Author Spotlight: Exploring Self-Assembled MOF-Polymer Composites
06:48

Author Spotlight: Exploring Self-Assembled MOF-Polymer Composites

Published on: June 14, 2024

2.5K

科学领域:

  • 材料科学 材料科学 材料科学
  • 纳米技术纳米技术
  • 生物技术是生物技术.

背景情况:

  • 分子印记聚合物纳米粒子 (nanoMIPs) 正在成为诊断和传感中抗体的强有力的合成替代品.
  • 固相合成参数对纳米MIP组成和性能的影响仍然未得到充分研究.
  • 了解这些参数对于优化各种应用的纳米MIP至关重要.

研究的目的:

  • 系统地比较玻璃珠和磁性纳米粒子固相协议用于纳米MIP合成.
  • 调查固体支和模板身份对纳米MIP特征的影响.
  • 为了评估在不同条件下合成的纳米MIP的结合性能和成分.

主要方法:

  • 在玻璃珠和磁性纳米粒子上准牛血红蛋白 (BHb) 和牛血清白蛋白 (BSA) 的NanoMIP合成.
  • 表面等离子体共振 (SPR) 测定以量化结合亲和力和动力学.
  • 1H核磁共振 (NMR) 光谱分析聚合物组成.

主要成果:

  • 固相选择显著影响 nanoMIP 颗粒大小,产量和结合亲和力.
  • 在玻璃珠上合成的纳米MIP显示其结合性能比磁性纳米颗粒高出十倍.
  • 1H NMR揭示了初始单体料比率和最终聚合物组成之间的显著差异,这取决于固态阶段和模板.

结论:

  • 固体支和模板身份极大地影响 nanoMIP 的特性和性能.
  • 考虑固相相互作用的合理设计对于开发高性能合成受体至关重要.
  • 这项研究为优化纳米MIP提供了一个框架,增强一致性,可重复性和商业潜力.