线粒细胞重编程乳酸代谢以通过H3K18la减少抑制THBS1,缓解椎间盘退化

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Kanbin Wang^1,2,3,4, Xiaoyong Wu^1,2,3,4, Hao Li^1,2,3,4

¹Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Research (Washington, D.C.)

|November 7, 2025

概括

线粒细胞吸收通过改变细胞代谢来减少椎间盘退化 (IVDD) 中的炎症. 这一过程降低了乳酸,减少了表观遗传修饰,并抑制了潜在的新IVDD疗法的炎症基因表达.

科学领域:

细胞生物学细胞生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
生物化学生物化学

背景情况:

椎间盘退化 (IVDD) 涉及炎症途径.
已知线粒可以缓解IVDD,但其代谢作用尚不清楚.

研究的目的:

调查菌体对IVDD产生影响的代谢机制.
为了确定IVDD的新型治疗点.

主要方法:

在衰老的核肉质 (NP) 细胞上使用了线粒活化剂TJ0113.
分析了新陈代谢变化,特别是乳酸生产和基因素乳酸化.
通过遗传和药理方法研究了乳酸-H3K18la-THBS1轴的作用.

主要成果:

线性活化剂TJ0113减少了老化的NP细胞中的乳酸生产.
降低乳酸降低了素H3素18乳酸化 (H3K18la).
这抑制了促炎性基因血栓松丁-1 (THBS1),阻断了炎症级联.

结论:

线细胞通过一种新的代谢-表观遗传轴 (乳酸盐-H3K18la-THBS1) 调节IVDD.
这个轴抑制炎症,并为IVDD提供潜在的治疗点.
突出了线粒在代谢重编程中的作用,用于对抗磁盘退化症的表观遗传疗法.

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