哈西莫托甲状腺炎对内镜甲状腺切除术在患有乳头甲状腺癌的患者中的影响
Zhen-Xin Chen1,2, Jing-Bao Chen1, Feng-Shun Pang1
1Department of Minimally Invasive Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China.
Frontiers in oncology
|November 7, 2025
概括
哈西莫托的甲状腺炎 (HT) 与乳头甲状腺癌 (PTC) 显示出不那么具有攻击性的瘤. 过口内镜甲状腺切除术 (TOETVA) 对于患有HT的PTC患者来说,比 transthoracic内镜甲状腺切除术 (ETCB) 更好.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 最少侵入性的手术
背景情况:
- 哈西莫托氏甲状腺炎 (HT) 经常与乳头甲状腺癌 (PTC) 一起发生.
- 甲状腺瘤的存在可能会使甲状腺切除手术过程复杂化.
- 甲状腺内镜手术在PTC患者的临床结果并未确立.
研究的目的:
- 通过前体方法 (TOETVA) 的横口内镜甲状腺切除术和通过胸部-乳房方法 (ETCB) 的内镜甲状腺切除术的临床结果在患有乳头甲状腺癌 (PTC) 和哈希莫托甲状腺炎 (HT) 的患者中进行比较.
- 为了评估HT对瘤特征和PTC患者进行内镜甲状腺切除术的外科结果的影响.
主要方法:
- 一个单一中心的回顾性研究,涉及500名患有PTC的患者,他们在2016年至2022年期间接受了内镜甲状腺切除术.
- 患者根据手术方法 (TOETVA或ETCB) 和HT的存在 (HT组与非HT组) 将患者分成两组.
- 收集的数据包括瘤阶段,淋巴结检索,手术时间和并发症率.
主要成果:
- 与非HT组相比,HT组的T1瘤比例较高,抽取的淋巴结数量较多,但阳性淋巴结较少.
- 所有内镜手术都成功完成,没有转换为开放手术.
- 与非HT组相比,HT组的ETCB方法与更长的手术时间和更高的并发症率 (过渡性甲状腺功能低下症,过渡性复发性喉神经损伤) 相关.
- 在TOETVA方法中,HT和非HT组之间在手术时间或并发症率上没有显著差异.
结论:
- 哈西莫托的甲状腺炎可能与乳头甲状腺癌中不太具有侵略性的瘤特征有关.
- 透口内镜甲状腺切除术通过前庭切除方法 (TOETVA) 可能是一个更有利的手术选择比内镜甲状腺切除术通过胸部-乳腺切除方法 (ETCB) 管理乳头甲状腺癌与并发的哈希莫托甲状腺炎.
- 建议进行进一步的前性研究来验证这些发现.
相关概念视频
Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...


