绘制肥胖和糖尿病五大并发症之间的相互作用的研究格局:使用知识图形可视化和知识图形可视化进行文献统计分析
Yutong Liu1, Yan Wang2, Xiaoming Tian3
1Affiliated Traditional Chinese Medicine Hospital of Binzhou Medical College (Binzhou Municipal Traditional Chinese Medicine Hospital), Binzhou, Shandong, China.
Frontiers in endocrinology
|November 7, 2025
概括
肥胖是连接五种主要糖尿病并发症的核心因素. 研究正在迅速发展,专注于炎症和新疗法等机制,突出强调体重管理.
科学领域:
- *内分泌学和新陈代谢学
- * * 公共卫生 公共卫生
- * 图书识别技术 图书识别技术
背景情况:
- * 肥胖是主要糖尿病并发症的重要危险因素,包括糖尿病病 (DKD),糖尿病血管病,糖尿病外围神经病,糖尿病视网膜病以及糖尿病足 (DFU).
- * 为了绘制研究格局并了解肥胖和这些糖尿病并发症之间的相互作用的智力结构,必须进行全面的文献分析.
- *现有研究强调了这种联系,但缺乏对相互联系和研究趋势的综合概述.
研究的目的:
- *系统地绘制全球研究趋势,关键主题,以及肥胖与糖尿病五大并发症之间的相互作用的新兴边界.
- *利用文献计量分析和知识图表可视化来理解这一研究领域的智力结构和演变.
- * 确定核心病理生理机制和未来研究方向.
主要方法:
- * 2015年1月1日至2025年3月17日期间发表的5475篇文章的综合图书统计分析,来自Web of Science,Scopus和PubMed.
- *使用VOSviewer和CiteSpace软件来分析共同引用,关键词共同出现和关键词突发事件.
- *绘制该领域的知识结构,协作网络和主题演变的地图.
主要成果:
- *该领域正在迅速发展,对糖尿病病 (DKD) 和糖尿病血管病的重要研究,由美国和中国的机构领导.
- * 关联肥胖和五种糖尿病并发症的核心病理生理机制包括"肥胖"",胰岛素耐药性"和"炎症".
- *研究已经从基础的关联发展到特定的分子途径,治疗干预,如"代谢手术",和不同的群体,如"儿童".
- * 肥胖研究形成了一个统一的智力支柱,整合了对糖尿病五大并发症的研究.
结论:
- * 肥胖症作为五大糖尿病并发症的科学联系,推动了快速进化的领域,并增加了机械复杂性.
- *研究结果支持将体重管理作为糖尿病治疗的核心组成部分.
- *未来的研究应该集中在治疗肥胖相关糖尿病并发症的基于机制的干预措施的临床转化上.
相关概念视频
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
230
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
230
Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Drug Dosing: Obese Patients
208
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
208
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K


