术后预后营养指数作为胃癌患者有用的预后因素
Masaaki Yamamoto1,2, Takeshi Omori1,3, Yasunori Masuike1
1Department of Gastroenterological Surgery Osaka International Cancer Institute Osaka Japan.
Annals of gastroenterological surgery
|November 7, 2025
概括
术后预后营养指数 (PNI) 是胃癌患者结果的有价值预测指标. 术后第一天PNI较低表明存活率较差,无复发存活率较低,突出显示了其预后意义.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 营养科学 营养科学
背景情况:
- 胃癌仍然是一个重大的全球健康挑战.
- 准确的预后因素对于优化患者管理和治疗策略至关重要.
- 在胃癌中术后预后营养指数 (PNI) 的实用性需要进一步研究.
研究的目的:
- 评估胃癌患者手术后预后营养指数 (PNI) 的预后价值.
- 确定PNI是否可以预测激进胃切除术后的无复发生存率和整体生存率.
主要方法:
- 一项对1635名经过激进胃切除术的胃癌患者的回顾分析.
- 评估各种生物标志物,包括术后第一和第三天的PNI,使用接收器操作特征曲线.
- 基于PNI水平的无复发生存率和总生存率的比较,使用日志等级测试和多变量Cox分析.
主要成果:
- 术后第一天的预后营养指数 (PNI) 显示出最高的预测准确度 (AUC=0.699).
- 在术后第一天PNI较低的患者的整体存活率和无复发存活率明显较差.
- 多变量分析证实了术后第一天的PNI作为总体和无复发生存时间的独立预后因素.
结论:
- 术后预后营养指数 (PNI) 是胃癌患者的重要和有用的预后因素.
- 早期术后PNI评估可以帮助分层患者和预测临床结果.
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