孕产妇肥胖现象型,代谢功能障碍和早产:一个潜在的出生队列研究
Jiayi Chen1,2, Yecheng Miao3, Qingxiu Li1,2
1Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Frontiers in nutrition
|November 7, 2025
概括
代谢异常和超重显著增加了早产 (PTB) 的风险. 超重和代谢不良的女性面临的PTB的机会大大增加,由于综合作用.
科学领域:
- 产科和妇科 产科和妇科
- 生殖健康 生殖健康
- 代谢健康 代谢健康
背景情况:
- 肥胖和代谢功能障碍是全球越来越多的健康问题.
- 了解它们对怀孕结果,特别是早产 (PTB) 的影响至关重要.
研究的目的:
- 调查代谢性肥胖表型与PTB之间的关联.
- 评估肥胖和代谢异常对PTB风险的综合影响.
主要方法:
- 在中国对20259名孕妇进行前性分娩队列研究.
- 代谢表型根据妊娠前的BMI和代谢状态进行分类.
- PTB定义为怀孕37周之前的分娩.
主要成果:
- 与较多的不良代谢成分一起观察到PTB的风险增加.
- 在代谢上不健康的正常体重和超重女性的PTB概率更高 (aOR1.33,1.62).
- 超重和代谢不健康之间对于PTB风险的显著相互作用 (RERI=0.41,AP=0.24,SI=2.22).
结论:
- 代谢异常和超重独立增加PTB风险.
- 在增加PTB风险方面,超重和代谢异常之间存在显著的协同相互作用.
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