在患有帕金森病和轻度认知障碍的人群中,认知表现和认知刺激功效的性别相关差异
Noemi Iaccino1, Jolanda Buonocore1,2, Giusi Torchia1
1Department of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.
Frontiers in aging neuroscience
|November 7, 2025
概括
这项研究揭示了认知功能和认知刺激 (CS) 对轻度认知障碍和帕金森病 (MCI-PD) 患者的有效性方面的性别差异. 调查结果强调需要针对性别量身定制的康复策略来改善结果.
科学领域:
- 神经科学是一个神经科学.
- 认知康复 认知康复 认知康复
- 老年学是一门学科.
背景情况:
- 现有关于与帕金森病 (MCI-PD) 轻度认知障碍的性别相关认知差异的研究提出了不一致的发现.
- 认知刺激 (CS) 是对MCI-PD的公认的非药物干预,但其跨性别的疗效仍然未被探索.
- 这项研究解决了了解MCI-PD患者的性别特异性认知特征和CS治疗反应的差距.
研究的目的:
- 调查MCI-PD患者在认知功能中的基于性别的差异.
- 评估认知刺激 (CS) 干预措施在MCI-PD患者群体中关于性别的有效性.
- 探索认知储备 (CR) 对MCI-PD认知表现和CS治疗结果的影响.
主要方法:
- 一组45名MCI-PD患者 (30名男性,15名女性) 参与了为期4周的CS计划,使用远程康复或亲自交付.
- 综合的神经心理评估,包括认知储备指数问卷,在基线,治疗后和6个月后续进行.
- 使用统计分析,包括调整的比较和回归模型,以确定与性别相关的差异和认知储备的影响.
主要成果:
- 与男性相比,患有MCI-PD的女性表现出较低的基线认知储备 (CR) 和在全球认知,注意力和视觉空间能力方面的表现较差,即使在CR调整后.
- 在CS之后,男性在多个认知领域 (全球认知,语言,执行功能,记忆,视觉空间,注意力) 显著改善,并减少了特征焦虑.
- 女性在全球认知和情绪方面表现出显著的改善. 在认知康复结果方面,男性的表现普遍优于女性的表现,无论交付方式如何. 在停止治疗后,认知能力的增长有所减少.
- 回归分析表明,CR对女性认知功能的调节效应更强.
结论:
- 在MCI-PD患者的认知功能和认知刺激 (CS) 的有效性方面存在显著的性别相关差异.
- 认知储备在调节这一群体的认知表现和治疗反应方面发挥着至关重要的作用,特别是对于女性来说.
- 这些发现强调了开发适合性别的认知康复策略的必要性,以优化治疗效率并提高MCI-PD患者的生活质量.
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