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Etlingera hemisphaerica可以调节化引起的Rattus norvegicus血清蛋白质的变化

Aceng Ruyani^1,2, Deni Parlindungan^2,3, Dian Samitra⁴

¹Graduate School of Science Education, Bengkulu University, Bengkulu, Indonesia.

Open veterinary journal

|November 7, 2025

概括

叶子乙醇提取物Etlingera hemisphaerica (LE3H) 有助于恢复暴露在化中的老鼠的正常蛋白质水平. 这表明LE3H可以通过调节血清蛋白来抵消毒性.

科学领域:

生物化学生物化学
毒理学毒理学毒理学
药理学药理学是指药理学的学科.

背景情况:

化 (HgCl2) 暴露会改变 *Rattus norvegicus* (老鼠) 的血清蛋白质概况.
*Etlingera hemisphaerica* (LE3H) 的叶子乙醇提取物已经显示出调节这些蛋白质变化的潜力.

研究的目的:

调查LE3H在恢复HgCl2引起的老鼠血清蛋白强度变化的有效性.
为了识别LE3H处理调节的特定蛋白质变化.

主要方法:

鼠被暴露在HgCl2中,随后用不同剂量的LE3H或对照物进行治疗.
使用洛瑞方法量化血清蛋白质水平.
用二维凝电泳和纳米液体染色学-双重质谱分析蛋白质用于识别.

主要成果:

HgCl2显著改变了大鼠血清中的16个蛋白质点的表达.
使用LE3H成功地将这些受影响蛋白质的表达水平恢复到控制水平.
通过NCBI加入号识别的特定蛋白质显示出由HgCl2显著调节,随后由LE3H恢复.

结论:

LE3H在减轻引起的全身毒性方面发挥了潜在的作用.
血清蛋白表达的调节是LE3H发挥其保护作用的关键机制.

关键词:

血清是血液中的血清.埃特林格拉半球美洲 (Etlingera hemisphaerica) 是一个半球的植物.化的化是一种.它们是Rattus norvegicus.这是一种二维蛋白质.

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